Florida Keys Road Trip: Best Rental Cars & Complete Driving Guide 2025
Guide12 min

Florida Keys Road Trip: Best Rental Cars & Complete Driving Guide 2025

Plan the perfect Florida Keys road trip from Miami. Discover the best rental cars, scenic stops, and insider tips for driving the Overseas Highway to Key West.

The drive from Miami to Key West along the Overseas Highway is one of the most spectacular road trips in the United States. Stretching 113 miles over the Atlantic Ocean and Gulf of Mexico, this engineering marvel connects a chain of tropical islands via 42 bridges, including the famous Seven Mile Bridge. Whether you are seeking adventure, relaxation, or simply an unforgettable driving experience, a Florida Keys road trip should be on every traveler's bucket list.

Planning your Florida Keys road trip starts with choosing the right rental car. The type of vehicle you select can significantly impact your experience on this iconic route. For couples or solo travelers, a convertible is the ultimate choice, allowing you to feel the warm tropical breeze and take in the panoramic ocean views without obstruction. The Ford Mustang Convertible and Chevrolet Camaro are popular options that combine style with the open-air experience.

For families or groups, a spacious SUV like the Audi Q7 or GMC Yukon provides comfort for the three to four hour drive while offering ample space for luggage, snorkeling gear, and beach supplies. These vehicles also handle well on the highway and provide a commanding view of the stunning scenery. If you are traveling with a larger group, consider the BMW X7 with its three rows of seating.

The journey begins in Miami, where you will head south on US-1, also known as the Overseas Highway. Before leaving the mainland, stop at the FloridaCity Walmart or Publix to stock up on snacks, drinks, and sunscreen, as prices increase significantly once you enter the Keys. The first major landmark is the Card Sound Road toll bridge, an alternative route that offers beautiful mangrove views and less traffic than the main highway.

Key Largo, the first and largest of the Florida Keys, is approximately 60 miles from Miami. This diving capital of the world is home to John Pennekamp Coral Reef State Park, the first undersea park in the United States. Even if you do not dive, the glass-bottom boat tours offer incredible views of the coral reef ecosystem. Key Largo is also an excellent spot for breakfast or an early lunch before continuing your journey.

Islamorada, known as the Sport Fishing Capital of the World, spans several islands and offers numerous attractions. Stop at Robbie's Marina to feed the giant tarpon, a unique Florida Keys experience that delights visitors of all ages. The History of Diving Museum and Theater of the Sea are also worth visiting if time permits. For food lovers, the fresh seafood restaurants along this stretch are among the best in the Keys.

The highlight of the drive is undoubtedly the Seven Mile Bridge, one of the longest bridges in the world when it was completed in 1982. This engineering masterpiece offers breathtaking views of the turquoise waters stretching to the horizon in every direction. Pull over at the old Seven Mile Bridge (now a pedestrian path) on the Marathon side for photos and to stretch your legs.

Marathon, located roughly halfway between Miami and Key West, makes an excellent stopping point. Visit the Turtle Hospital for a guided tour and learn about sea turtle conservation efforts. The town also offers good restaurants, beaches, and the opportunity to swim with dolphins at the Dolphin Research Center on nearby Grassy Key.

Bahia Honda State Park, just past the Seven Mile Bridge, features some of the most beautiful beaches in the Florida Keys. The crystal-clear water and white sand beaches are perfect for swimming, snorkeling, or simply relaxing. This is an ideal spot for a picnic lunch with your rental car parked in the shade of Australian pines.

Big Pine Key is home to the National Key Deer Refuge, where you might spot the endangered Key deer, a miniature subspecies found nowhere else on Earth. Drive slowly through this area, especially at dawn and dusk when deer are most active. The Blue Hole, a former quarry now filled with fresh water and home to alligators, is another unique attraction.

The final stretch to Key West takes you through the Lower Keys, including Sugarloaf Key and Stock Island. As you approach Key West, the southernmost city in the continental United States, you will notice the architecture becoming more colorful and the atmosphere more festive. Key West offers endless attractions, from the Ernest Hemingway Home to Mallory Square's famous sunset celebration.

For your return trip, consider staying overnight in Key West to fully experience the island's unique culture and nightlife. The drive back to Miami can be done in one day, but breaking it up with stops allows you to explore attractions you might have missed on the way down. Many travelers choose to rent their car through Turo for the flexibility of extended rentals and unique vehicle options.

Essential tips for your Florida Keys road trip: Start early to avoid traffic and maximize daylight hours. Keep your gas tank at least half full, as gas stations become less frequent in the Lower Keys. Bring reef-safe sunscreen to protect both yourself and the delicate marine ecosystem. Finally, check bridge conditions before traveling, as occasional closures for maintenance can affect your route.

The Florida Keys road trip is more than just a drive; it is a journey through one of America's most unique landscapes. With the right rental car from Miami and a sense of adventure, you will create memories that last a lifetime.

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Sarah Johnson

1/22/2025

Great article! Very helpful information about car rentals in Miami. I'm planning a trip next month and this guide answered all my questions.

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Vela Global Team
1/22/2025

Thank you Sarah! We're glad this guide was helpful. Feel free to contact us if you need any assistance with your booking.

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Michael Chen

1/21/2025

I used Turo for the first time last week based on this article. The experience was amazing! Much better than traditional rental companies.

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Maria Rodriguez

1/20/2025

Excelente artículo! La información sobre Fort Lauderdale es muy útil. ¿Tienen descuentos para alquileres de más de una semana?

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